Which vitamin is crucial for collagen synthesis in the body?

Vitamin C is crucial for collagen synthesis in the body because it acts as a cofactor for the enzymes prolyl hydroxylase and lysyl hydroxylase. These enzymes are necessary for the post-translational modification of collagen, specifically hydroxylating proline and lysine residues. This hydroxylation is essential for the stability and strength of collagen fibers, contributing to the structural integrity of connective tissues, skin, cartilage, and bones.

Without sufficient vitamin C, collagen synthesis is impaired, leading to various health issues, including scurvy, characterized by weakened connective tissues, bleeding gums, and joint pain. The role of vitamin C in collagen production is so pivotal that it is often highlighted in discussions about skin health and wound healing, emphasizing its importance in maintaining overall health and well-being. This foundational role is why vitamin C is recognized as an essential nutrient for collagen synthesis.